SiRNA-Mediated Reduction of α-Actinin-1 Inhibits Pressure-Induced Murine Tumor Cell Wound Implantation and Enhances Tumor-Free Survival
نویسندگان
چکیده
منابع مشابه
SiRNA-mediated reduction of alpha-actinin-1 inhibits pressure-induced murine tumor cell wound implantation and enhances tumor-free survival.
Viable cancer cells can commonly be recovered from surgical sites and venous blood during tumor resection. The adhesion of these cells to surrounding tissues may impact patient outcomes. Iatrogenic exposure to increased extracellular pressure modulates integrin binding affinity and stimulates colon cancer cell adhesion in vitro through an alpha-actinin-1-dependent signaling pathway. We hypothes...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2008
ISSN: 1476-5586
DOI: 10.1593/neo.07945